This was discussed in detail about a year ago; I think the general
conclusion is that if you are in the US you can't go wrong with luggage
from either of the three major players: Hartmann, Andiamo, or Tumi. As
far as I can tell a wheeled 'backpack' does neither job well.

Javaman wrote:

I'm interested in buying a wheeled backpack, one that meets carry-on
requirements (22").